Congratulations to Marco Jost for his paper titled “Visualization of a Radical B12 Enzyme with its G-protein Chaperone” being published by PNAS.
The structures of the complex between this G-protein metallochaperone and one of its target proteins, a radical B12 enzyme, reveal the molecular architecture and the pathways that both sense and report on the cofactor loading state. The structures provide broad insight into Nature’s strategies to handle precious metallocofactors.