Updated: July 2019

Wittenborn, E.C., Cohen, S.E., Merrouch, M., Léger, C., Fourmond, V., Dementin, S., and Drennan, C.L. (2019) Structural insight nto metallocofactor maturation in carbon monoxide dehydrogenase, J. Bio. Chem. 2019 July 11. doi: 10.1074/jbc.RA119.009610 Full text at JBC

Bowman, S.E.J., Backman, L.R.F., Bjork, R.E., Andorfer, M.A., Yori, S., Caruso, A., Stultz,C.M, and Drennan, C.L. (2019) Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme, J. Biol. Inorg. Chem. 2019 June 27. doi: 10.1007/s00775-019-01681-2 Full text at JBIC

Chen, P.Y-T., DeColli, A.A., Freel Meyers, C.L., and Drennan, C.L. (2019) X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-D-xylulose 5-phosphate synthase reaction coordinate, J. Bio. Chem. 2019 June 25. doi: 10.1074/jbc.RA119.009321 Full text at JBC

Rizzolo, K., Cohen, S.E., Weitz, A.C., López Muñoz, M.M., Hendrich, M.P., Drennan, C.L., and Elliott, S.J. (2019) A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state, Nat. Commun. 2019 Mar. 7. doi: 10.1038/s41467-019-09020-4 Full text at Nat. Commun.

Feliciano, P.R., Drennan*, C.L., and Nonato*, M.C. (2019) Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate, ACS Chem. Biol. 2019 Jan. 15. doi: 10.1021/acschembio.8b00972 Full text at ACS Chem Biol

Chen, P.Y-T., Li, Bin, Drennan*, C.L., and Elliott*, S.J. (2019) A Reverse TCA Cycle 2-Oxoacid:ferredoxin Oxidoreductase that Makes C-C Bonds from CO, Joule online 2019 Jan. 4. doi:0.1016/j.joule.2018.12.006 Full text

Grell, T.A.J., Bell, B.N., Nguyen, C., Dowling, D.P., Bruender, N.A., Bandarian, V., Drennan, C.L. (2018) Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity Protein Sci. 2018 Oct. 19. doi: 10.1002/pro.3529 PMID:30341796 Full text

Grell, T.A.J., Kincannon, W.M., Bruender, N.A., Blaesi, E.J., Kreb, C., Bandarian, V., Drennan, C.L. (2018)  Structural and Spectroscopic Analyses of the Sporulation Killing Factor Biosynthetic Enzyme SkfB, a Bacterial AdoMet Radical Sactisynthase J. Bio. Chem. 2018 Sept 14. pii:jbc.RA118.005369 doi: 10.1074/jbc.RA118.005369 [Epub ahead of print] PMID: 30217813 Full text at J Bio Chem

Wittenborn, E.C., Merrouch, M., Ueda, C., Fradale, L., Léger, C., Fourmond, V., Pandelia, M-E., Dementin*, S.,  and Drennan*, C.L. (2018) Redox-dependent Rearrangements of the NiFeS Cluster of Carbon Monoxide Dehydrogenase, eLife 2018;7:e39451. doi: 10.7554/eLife.39451 Full text at eLife

Ryan, K.S. and Drennan, C.L. (2018) Metalloproteins in Natural Product Biosynthetic Pathways, Nat. Prod. Rep. 35, 616-614. doi: 10.1039/C8NP90023J Full text

Harris, N.C., Born, D.A., Cai, W., Huang, Y., Martin, J., Khalaf, R., Drennan, C.L., and Zheng*, W. (2018) Isonitrile Formation by a Non-heme Iron(II)-Dependent Oxidase/Decarboxylase, Angew. Chemie Int. Ed., doi: 10.1002/anie.201804307 PMCID: In Progress. Full text

Toshiki, T.G., Bowman, S.E.J. Zygiel, E.M., Drennan*, C.L., and Nolan*, E.M. (2018) Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site, Biochemistry 57, 4155-4164. PMCID: PMC6050108 Full text at Biochemistry

Grell, T.A.J., Young, A.P., Drennan, C.L., and Bandarian, V. (2018) Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1, J. Am. Chem. Soc. 140, 6842-6852. PMCID: PMC5994729 Full text at JACS

Chen, P.Y.-T., Funk, M.A., Brignole, E.J., and Drennan, C.L.  (2018) Disruption of an Oligomeric Interface Prevents Allosteric Inhibition of Escherichia coli class Ia Ribonucleotide Reductase  J. Biol. Chem.  Apr 26. pii: jbc.RA118.002569. doi: 10.1074/jbc.RA118.002569. [Epub ahead of print]   PMID 29700111   Full text at JBC

Chen, P.Y-T., Aman, H., Can, M., Ragsdale, S.W., and Drennan, C.L. (2018) Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreducatase from Moorella thermoacetica, Proc. Natl. Acad. Sci. U.S.A. 2018 Mar 26. pii: 201722329. doi: 10.1073/pnas.1722329115. [Epub ahead of print]  PMC5899475   Full text at PNAS

Brignole E.J., Tsai, K.L., Chittuluru,  J., Li, H., Aye, Y., Penczek, P.A., Stubbe, J., Drennan, C.L., and Asturias, F.  (2018)  3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. eLife. Feb 20, 2018;7. pii: e31502.  PMC5819950.  Full text at eLife

Born, D.A., Ulrich, E.C., Ju, K.S., Peck, S.C., van der Donk, W.A., and Drennan, C.L. (2017)  Structural basis for methylphosphonate biosynthesis, Science  Dec 8;358(6368):1336-1339. doi: 10.1126/science.aao3435.  PMC5901744  Full text at Science

Backman, L.R.F., Funk, M.A., Dawson, C.D., and Drennan, C.L. (2017) New tricks for the glycyl radical enzyme family, Critical Reviews In Biochemistry & Molecular Biology, Dec;52(6):674-695. doi: 10.1080/10409238.2017.1373741. Epub 2017 Sep 13.  PMC5911432   Full text

Shisler, K., Hutcheson, R., Horitani, M., Duschene, K., Crain, A., Byer, A., Shepard, E., Rasmussen, A., Yang, J., Broderick, W., Vey, J., Drennan, C.L., Hoffman, B., and Broderick, J.  (2017) Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme, J. Am. Chem. Soc., 139 (34), pp 11803–11813  Full text at J. Am. Chem. Soc.

Bridwell-Rabb, J., Zhong, A., Sun, H.G., Drennan, C.L., and Liu, H.-w.  (2017) A B12-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis, Nature AOP, doi:10.1038/nature21689. PMC5398914  Full text at Nature

Kung, Y., and Drennan, C.L. (2017)  One-Carbon Chemistry of Nickel-Containing Carbon Monoxide Dehydrogenase and Acetyl-CoA Synthase.  In The Biological Chemistry of Nickel, D. Zamble, M. Rowinska-Zyrek, H. Kozlowski, eds., Royal Society of Chemistry, London, pp. 121-148

Cory, S.A., Van Vranken, J.G., Brignole, E.J., Patra, S., Drennan, C.L., Rutter, J., and Barondeau, D.P. (2017) Structure of Human Fe-S Assembly Sub-complex Reveals Unexpected Cysteine Desulfurase Architecture and Acyl-ACP-ISD11 Interactions, Proc. Natl. Acad. Sci. U.S.A., doi:10.1073/pnas.1702849114.  PMC5502623  Full text at PNAS

Lin, Q., Parker, M.J., Taguchi, A.T., Ravichandran, K., Kim, A., Kang, G., Drennan, C.L., and Stubbe, J. (2017) Glutamate 52-b at the a/b Subunit Interface of E. coli Class Ia Ribonucleotide Reductase is essential for Conformational Gating of Radical Transfer, J. Biol. Chem. doi: 10.1074/jbc.M117.783092.  Full text at J. Biol. Chem.

Nakashige, T.G., Zygiel, E.M., Drennan, C.L., and Nolan, E.M. (2017) Nickel Sequestration by the Host-Defense Protein Human Calprotectin, J. Am. Chem. Soc. 139, 8828–8836. PMCID:C5754018. [Available on 2018-07-05]; doi:10.1021/jacs.7b01212.  Full text at JACS

Padmanabhan, S., Jost, M., Drennan, C.L., and Elias-Arnanz, M. (2017) A New Facet of Vitamin B12: Gene Regulation by Cobalamin-based Photoreceptors, Ann. Rev. Biochem. 86, 485-514.  Full text at Ann. Rev. Biochem.

Bridwell-Rabb, J., and Drennan, C.L. (2017) Vitamin B12 in the Spotlight Again, Curr. Op. Chem. Biol. 37, 63-70PMC5540639   Full text at ScienceDirect

Bruender, N.A., Grell, T.A.J., Dowling, D.P., McCarty, R.M., Drennan, C.L., and Bandarian, V. (2017) 7-Carboxy-7-deazaguanine synthase – A radical S-adenosyl-L-methionine enzyme with polar tendencies, J. Am. Chem. Soc. 139, 1912-1920PMC5301278  Full text at JACS

Bridwell-Rabb, J., Kang, G., Zhong, A., Liu, H.-w., and Drennan, C.L. (2016) An HD-domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis, Proc. Natl. Acad. Sci. U.S.A., 113, 12432-12437.  PMC5137760.  Full text at PNAS

Wittenborn, E.C., Jost, M., Wei, Y., Stubbe, J., and Drennan, C.L. (2016) Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator, J. Biol. Chem. jbc.M116.756833. doi:10.1074/jbc.M116.756833 Full text at JBC

Dowling, D.P., Kung, Y., Croft, A.,K., Taghizadeh, K., Kelly, W.L., Walsh, C.T., and Drennan, C.L. (2016) Structural elements of an NRPS cyclization domain and its intermodule docking domain, Proc. Natl. Acad. Sci. U.S.A., Published Online October 17, 2016, doi:10.1073/pnas.1608615113   PMC5098645  Full text at PNAS

Dowling, D.P., Miles, Z.D., Köhrer, C.; Maiocco, S.J., Elliott, S.J., Bandarian, V., and Drennan, C.L. (2016) Molecular basis of cobalamin-dependent RNA modification, Nucleic Acids Research, doi: 10.1093/nar/gkw806. Full text at NAR

Bodea, S., Funk, M.A., Balskus, E.P., and Drennan, C.L. (2016) Molecular Basis of C–N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-lyase, Cell Chem. Biol. 23, 1206-1216. doi:10.1016/j.chembiol.2016.07.020  Full text at Cell Chemical Biology

Feliciano, P.R., Drennan, C.L., and Nonato, M.C. (2016) Crystal Structure of an Fe-S Cluster-Containing Fumarate Hydratase Enzyme from Leishmania major Reveals an Unique Protein Fold, Proc. Natl. Acad. Sci. U.S.A., doi:10.1073/pnas.1605031113 Full text at PNAS

Gibson, M.I., Chen, P.Y.-T., and Drennan, C.L. (2016) A Structural Phylogeny for Understanding 2-Oxoacid Oxidoreductase Function, Current Opinion in Structural Biology pp. 54-60. doi: 10.1016/ Full text at Science Direct

McLaughlin, M.I., Lanz, N.D., Goldman, P.J., Lee, K.-H., Booker, S.J., and Drennan, C.L. (2016) Crystallographic snapshots of sulfur insertion by lipoyl synthase, Proc. Natl. Acad. Sci. U.S.A., PMC5003258  Full text at PNAS

Oyala, P.H., Ravichandran, K.R., Funk, M.A., Stucky, P.A., Stich, T.A., Drennan, C.L., Britt, R.D., and Stubbe, J. (2016) Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example, J. Am. Chem. Soc. 138(25), 7951-7964  Full text at JACS

Bridwell-Rabb, J., and Drennan, C.L. (2016) A radically unexpected mechanism, Science, 351(6279), 1266-1267  Full text at Science, PDF

Meyer, P.A., et al. (2016) Data publication with the structural biology data grid supports live analysis, Nature Communications, 7, 1-12. doi:10.1038/ncomms10882  Full text at Nature

Bowman, S.E.J, Bridwell-Rabb, J., and Drennan, C.L. (2016) Metalloprotein crystallography: more than a structure, Accounts of Chemical Research, Article ASAP. doi: 10.1021/acs.accounts.5b00538 ACS Editor’s Choice, Full text at ACS

Chen, F., Tang, Q., Bian, K., Humulock, Z.T., Yang, X., Jost, M., Drennan, C.L., Essigman, J.M., and Li, D. (2016) Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA, Chem. Res. Toxicol., 29(4), 687-693  Full text at ACS

Chen, P.Y-T., Wittenborn, E.C., and Drennan, C.L. (2016) Nitrogen Fixation: Waltzing around cofactors, eLife 2016;5:e13977. doi: 10.7554/eLife.13977 Full text at eLife

Zimanyi, C.M., Chen, P.Y.-T., Kang, G., Funk, M.A., and Drennan, C.L. (2016) Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia colieLife 2016;5:e07141. doi: 10.7554/eLife.07141 Full text at eLife

Gibson, M.I., Chen, P.Y.-T., Johnson, A.C., Pierce, E., Can, M., Ragsdale, S.W., and Drennan, C.L. (2016) One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography, Proc. Natl. Acad. Sci. U.S.A. 113(2), 320-325. doi: 10.1073/pnas.1518537113  Full text at PNAS

Ando, N., Li, H., Brignole, E.J., Thompson, S., McLaughlin, M.I., Page, J.E., Asturias, F.J., Stubbe, J., and Drennan, C.L. (2016) Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer, Biochemistry, 55(2), 373-381. Full text at ACS

Jost, M., Born, D.A., Cracan, V.F., Banerjee, R., and Drennan, C.L. (2015) Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases, J. Biol. Chem., 290, 26882-26898. PMID 26318610 Full text at JBC

Jost, M., Fernández-Zapata, J., Polanco, M.C., Ortiz-Guerrero, J.M., Chen, P.Y.-T., Kang, G., Padmanabhan. S., Elías-Arnanz, M., and Drennan, C.L. (2015) Structural Basis for Gene Regulation by a B12-dependent Photoreceptor, Nature doi:10.1038/nature14950 Full text at Nature

Jost, M., Simpson, J.H., and Drennan, C.L. (2015) The Transcription Factor CarH Safeguards Use of Adenosylcobalamin as a Light Sensor by Altering the Photolysis Products, Biochemistry, 54, 3231-4. PMCID: PMC4455981 Full text at ACS Publications

Bewley, K.D., Dey, M., Bjork, R.E., Mitra, S., Chobot, S.E., Drennan, C.L., and Elliott, S.J. (2015) Rheostat Re-wired: Alternate Hypotheses for the Control of Thioredoxin Reduction Potentials, PLOS ONE, 10, e0122466. doi: 10.1371/journal.pone.0122466. eCollection  PMC4395160 Full text at PLOS ONE

Mattaini, K.R., Brignole, E.J,, Kini, M., Davidson, S.M., Fiske, B.P., Drennan, C.L., and Vander Heiden, M.G. (2015) An Epitope Tag Alters Phosphoglycerate Dehydrogenase Structure and Impairs Ability to Support Cell Proliferation, Cancer & Metabolism, 3: 5. doi: 10.1186/s40170-015-0131-7 eCollection.  PMC4414297 Full text at Cancer & Metabolism

Funk, M.A., Marsh, E.N.G., and Drennan, C.L. (2015). Substrate-bound Structures of Benzylsuccinate Synthase Reveal How Toluene is Activated in Anaerobic Hydrocarbon Degradation. J. Biol. Chem., doi: 10.1074/jbc.M115.670737. Full text at JBC

Gibson, M.I., Brignole, E.J., Pierce, E., Can, M., Ragsdale, S.W., and Drennan, C.L. (2015). The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism. Biochemistry, 54 (26), 4112-4120. Full text at ACS Publications

Chang, S.C., Fedeles, B.I., Wu, J., Delaney, J.C., Li, D., Zhao, L., Christov, P.P., Yau, E., Singh, V., Jost, M., Drennan, C.L., Marnett, L.J., Rizzo, C.J., Levine, S.S., Guengerich, F.P., and Essigmann, J.M. (2015). Next-generation sequencing reveals the biological significance of the N2, 3-ethenoguanine lesion in vivo. Nucleic Acids Research, 43, 5489-5500. Full text NAR

Jost, M., Cracan, V., Hubbard, P.A., Banerjee, R., and Drennan, C.L. (2015). Visualization of a radical B12 enzyme with its G-protein chaperone. Proceedings of the National Academy of Sciences112(8), 2419-2424. Full text at PNAS

Gagnon, D.M., Brophy, M.B., Bowman, S.E., Stich, T.A., Drennan, C.L., Britt, R.D., and Nolan, E.M. (2015). Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis. Journal of the American Chemical Society. Full text at ACS Publications

Grell, T.A., Goldman, P.J., and Drennan, C.L. (2014). SPASM and Twitch Domains in AdoMet Radical Enzyme Structures. Journal of Biological Chemistry, jbc-R114. Full text at JBC

Setser, J.W., Heemstra Jr, J.R., Walsh, C.T., and Drennan, C.L. (2014). Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase. Biochemistry53(38), 6063-6077.  Full text at ACS Publications

Wei, Y., Funk, M.A., Rosado, L.A., Baek, J., Drennan, C.L., and Stubbe, J. (2014). The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proceedings of the National Academy of Sciences111(36), E3756-E3765. Full text at PNAS

Liu, D.S., Nivón, L.G., Richter, F., Goldman, P.J., Deerinck, T.J., Yao, J.Z., Richardson, D., Phipps, W.S., Ye, A., Hell, S.W., Ellisman, M.W., Drennan, C.L., Baker, D., and Ting, A.Y. (2014). Computational design of a red fluorophore ligase for site-specific protein labeling in living cells. Proceedings of the National Academy of Sciences111(43), E4551-E4559. Full text at PNAS

Funk, M.A., Judd, E.T., Marsh, E.N.G., Elliott, S.J., and Drennan, C.L. (2014). Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity. Proceedings of the National Academy of Sciences, 111(28), 10161-10166. Full text at PNAS

Dowling, D.P., Bruender, N.A., Young, A.P., McCarty, R.M., Bandarian, V., and Drennan, C.L. (2013). Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biologydoi:10.1038/nchembio.1426 Access the recommendation on F1000Prime

Goldman, P.J., Grove, T.L., Booker, S.J., and Drennan, C.L. (2013). X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proceedings of the National Academy of Sciences, 110(40), 15949-15954. Full text at PNAS

Goldman, P.J., Grove, T.L., Sites, L.A., McLaughlin, M.I., Booker, S.J., and Drennan, C.L. (2013). X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proceedings of the National Academy of Sciences110(21), 8519-8524. Full text at PNAS

Li, D., Fedeles, B.I., Shrivastav, N., Delaney, J.C., Yang, X., Wong, C., Drennan, C.L., and Essigmann, J.M. (2013). Removal of alkylation DNA adducts from N 2-alkylguanine and N 4-alkylcytosine by the adaptive response protein AlkB.Chemical research in toxicology. Full text at ACS Publications

Sydor, A.M., Jost, M., Ryan, K.S., Turo, K.E., Douglas, C.D., Drennan,  C.L., and Zamble,  D.B. (2013) Metal Binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases. Biochemistry 52 (10) 1788–1801. Full text at ACS Publications

Kulik, H.J., and Drennan,  C.L. (2013) Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases. J. Biol. Chem. doi: 10.1074/jbc.M112.415570. Full text at JBC

Minnihan, E.C., Ando, N., Brignole, E.J., Olshansky, L., Chittuluru, J., Asturias, F.J., Drennan, C.L., Nocera, D.G., and Stubbe, J. (2013) Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proc. Natl. Acad. Sci. U.S.A. 110 (10) 3835–3840 Full text at PNAS

Chang,W-C., Dey, M., Liu, P,, Mansoorabadi, S.O., Moon, S., Zhao, Z.K., Drennan. C.L., and Liu, H-W. (2013) Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature 496, 114–118. Full text at Nature

Brignole EJ, Ando N, Zimanyi CM, Drennan CL. (2013) The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years. Biochemical Society Transactions 40 523–530. PMC5912335     Full text online

Li D, Delaney JC, Page CM, Yang X, Chen AS, Wong C, Drennan CL, Essigmann JM. (2012) Exocyclic Carbons Adjacent to the N6 of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB. J. Am. Chem. Soc. 134 (21) 8896–8901. Full text at ACS Publications

Ando N, Kung Y, Can M, Bender G, Ragsdale SW, Drennan CL. (2012) Transient B12-Dependent Methyltransferase Complexes Revealed by Small-Angle X-ray Scattering. J. Am. Chem. Soc. 134 (43) 17945–17954. Full text at ACS Publications

Bewley, K.D., Firer-Sherwood, M.A., Mock, J.-Y., Ando, N., Drennan, C.L. and Elliott, S.J. (2012) Mind the Gap: Diversity and Reactivity Relationships Among Multihaem Cytochromes of the MtrA/DmsE Family, Biochem. Soc. Trans. 40, 1268-1273.  doi:10.1042/BST20120106  PMC5906043  Full text at Bioch. Soc. Trans.

Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. (2012) An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes. Chemistry & Biology 19, 855-865. Full text at Cell Press

Aye Y, Brignole EJ, Long MJC, Chittuluru J, Drennan CL Asturias FJ, Stubbe J. (2012) Clofarabine Targets the Large Subunit (alpha) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers. Chemistry & Biology 19, 799-805. Full text at Cell Press

Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. (2012) Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase. Structure. 20 (8), 1374-1383. Full text at ScienceDirect

Dowling DP, Vey JL, Croft AK, and Drennan CL. (2012) Structural diversity in the AdoMet radical enzyme superfamily. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics. 1824, 1178-1195. Full text at ScienceDirect

Dowling DP, Croft AK, and Drennan CL. (2012) The Radical Use of Rossmann and TIM Barrel Architectures for Controlling Coenzyme B12 Chemistry. Annual Review of Biophysics 41, 403-427. Full text at Annual Reviews

Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, and Drennan CL. (2012) Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature 48, 265-269. Full text at Nature

Setser JW, Lingaraju GM, Davis CA, Samson LD, Drennan CL. (2012) Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase. Biochemistry 51, 382-390. Full text at ACS Publications

Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. (2011) Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proc. Natl. Acad. Sci. U.S.A. 108, 21046-21051. Full text at PNAS

Hamill MJ, Jost M, Wong C, Bene N, Drennan CL, Elliott SJ. (2011) Electrochemical Characterization ofEscherichia coli adaptive response protein AidB. Int J Mol Sci 13, 16899-16915. Full text

Anderson WA, Amasino RM, Ares M Jr, Banerjee U, Bartel B, Corces VG, Drennan CL, Elgin SC, Epstein IR, Fanning E, Guillette LJ Jr, Handelsman J, Hatfull GF, Hoy RR, Kelley D, Leinwand LA, Losick R, Lu Y, Lynn DG, Neuhauser C, O’Dowd DK, Olivera T, Pevzner P, Richards-Kortum RR, Rine J, Sah RL, Strobel SA, Walker GC, Walt DR, Warner IM, Wessler S, Willard HF, Zare RN. (2011) Competencies: a cure for pre-med curriculum. Science 334, 760-761. Full text at Science

Hamill MJ, Jost M, Wong C, Elliott SJ, Drennan CL. (2011) Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB. Biochemistry 50, 10159-10169. Full text at ACS Publications

Firer-Sherwood MA, Ando N, Drennan CL, Elliott SJ. (2011) Solution-Based Structural Analysis of the Decaheme Cytochrome, MtrA, by Small-Angle X-ray Scattering and Analytical Ultracentrifugation. J. Phys. Chem. B 115, 11208-11214. Full text at ACS Publications

Anderson WA, Banerjee U, Drennan CL, Elgin SC, Epstein IR, Handelsman J, Hatfull GF, Losick R, O’Dowd DK, Olivera BM, Strobel SA, Walker GC, Warner IM. (2011) Science education. Changing the culture of science education at research universities. Science 331, 152-153. Full text at Science

Yun D, Dey M, Higgins LJ, Yan F, Liu H-W, Drennan CL. (2011) Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis. J. Am. Chem. Soc. 131, 11262-11269.Full text at ACS Publications

Lingaraju GM, Davis CA, Setser JW, Samson LD, Drennan CL. (2011) Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4 -ethenocytosine-containing DNA. J. Biol. Chem. 286, 13205-13213. Full text at JBC

Vey JL and Drennan CL. (2011) Structural Insights into Radical Generation by the Radical SAM Superfamily. Chem. Rev. 111, 2487-2506. Full text at ACS Publications

Kung Y and Drennan CL. (2011) A Role for Nickel-Iron Cofactors in Biological Carbon Monoxide and Carbon Dioxide Utilization. Curr. Opin. Biol. Chem. 15, 276-283. Full text at ScienceDirect

Li D, Delaney J, Page C, Chen A, Wong C, Drennan CL, Essigmann JM. (2010) Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry. J. Nucleic Acids 2010. doi: 10.4061/2010/369434.

Drennan CL. (2010) In the nickel of time. Nat. Chem. 10, 900.

Phillips CM, Schreiter ER, Stultz CM, and Drennan CL. (2010) Structural Basis of Low Affinity Nickel Binding to the Nickel-Responsive Transcription Factor NikR from Escherichia coliBiochemistry. 49:7830-7838.

Phillips CM, Stultz CM, and Drennan CL. (2010) Searching for the nik Operon: How a Ligand-responsive Transcription Factor Hunts for its DNA Binding Site. Biochemistry49:7757-7763.

Taylor EV, Fortune JA, Drennan CL. (2010) A Research-inspired Laboratory Sequence Investigating Acquired Drug Resistance. Biochem. Mol. Biol. Educ. 38:247-252.

Taylor EV, Mitchell R, Drennan CL. (2009) Creating an Interdisciplinary Introductory Chemistry Course without Time-Intensive Curriculum Changes. ACS Chem. Biol4:979-982.

Kulik HJ, Blasiak LC, Marzari N, Drennan CL. (2009) First Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity. J. Am. Chem. Soc131:14426-14433.

Drennan CL and Jarrett JT. (2009) From Single Molecules to Whole Organisms: The Evolving Field of Mechanistic Enzymology. Curr. Opin. Chem. Biol13:433-435.  Full text

Kung Y, Doukov TI, Seravalli J, Ragsdale SW, Drennan CL. (2009) Crystallographic Snapshots of Cyanide- and Water-Bound C-Clusters from Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.Biochemistry48(31):7432-7440.

Phillips CM, Nerenberg PS, Drennan CL, Stultz CM. (2009) Physical Basis of Metal-Binding Specificity inEscherichia coli NikR. J. Am. Chem. Soc. 131(29):10220-10228.

Ryan KS and Drennan CL. (2009) Divergent Pathways in the Biosynthesis of Bisindole Natural Products.Chem. Biol. 16:351-364.

Wong C, Fujimori DG, Walsh CT and Drennan CL. (2009) Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3. J. Am. Chem. Soc. 191:4972-4979.

Blasiak, LC and Drennan CL. (2009) Structural Perspective on Enzymatic Halogenation. Acc. Chem. Res.42(1):147-155.

Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. (2008) The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction. Biochemistry47:14506-13513.

Vey JL, Yang J, Li M, Broderick WE, Broderick JB, Drennan CL. (2008) Structural Basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proc. Natl. Acad. Sci. U.S.A. 105(42):16137-16141.

Phillips CM and Drennan CL. (2008) Nickel regulatory transcription factor, NikR. Handbook of Metalloproteins.

Blasiak LC and Drennan CL. (2008) Nonheme iron halogenases. Handbook of Metalloproteins.

Hernandez HH, Jaquez OA, Hamill MJ, Elliott SJ, Drennan CL. (2008) Thioredoxin Reductase fromThermoplasma acidophilum: A New Twist on Redox Regulation. Biochemistry47(37):9728-9737.

Hamill MJ, Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. (2008) Direct Electrochemical Analyses of a Thermophilic Thioredoxin Reductase: Interplay between Conformational Change and Redox Chemistry.Biochemistry47(37):9738-9746.

Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. (2008) The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins. J. Biol. Chem. 283(10):6467-6475.  Full article

Doukov TI, Blasiak LC, Seravalli J, Ragsdale SW, Drennan CL. (2008) Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase. Biochemistry47(11):3474-3483.

Phillips CM, Schreiter ER, Guo Y, Wang SC, Zamble DB, Drennan CL. (2008) Structural Basis of the Metal Specificity for Nickel Regulatory Protein NikR. Biochemistry47(7):1938-1946.  Full text at ACS Publications

Hubbard PA, Padovani D, Labunska T, Mahlstedt SA, Banerjee R, Drennan CL. (2007) Crystal Structure and Mutagenesis of the Metallochaperone MeaB. J. Biol. Chem. 282(43):31308-31316.  Full article

Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. (2007) Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proc. Natl. Acad. Sci. U.S.A. 104(39):15311-15316.  Full article

Schreiter ER and Drennan CL. (2007) Ribbon-helix-helix transcription factors: variations on a theme. Nat. Rev. Microbiol. 5(9):710-720.  Full article

Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. (2007) Direct Electrochemical Characterization of Archeael Thioredoxins. Angew. Chem. Int. Ed. Engl. 46(22):4145-4147.  Full article

Doukov TI, Hemmi H, Drennan CL, Ragsdale SW. (2007) Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer: Role of an active site asparagine residue in activation of methyl transfer by methyltransferases. J. Biol. Chem. 282(9):6609-6618.  Full article

Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. (2007) Chlorination by a Long-Lived Intermediate in the Mechanism of Flavin-Dependent Halogenases. Biochemistry46(5):1284-1292.  Full article

Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM. (2007) Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc. Natl. Acad. Sci. U.S.A.104(3):755-760.  Full article

Blasiak LC, Vaillancourt FH, Walsh CT, Drennan CL. (2006) Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature. 440:368-371. Full article

Schreiter ER, Wang SC, Zamble DB, Drennan CL. (2006) NikR-operator Complex Structure and the Mechanism of Repressor Activiation by Metal Ions. Proc. Natl. Acad. Sci. U.S.A. 103(37):13676-13681.  Full article

Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh L, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. (2005) AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivoNat. Struct. Mol. Biol. 12(10):855-860.  Full article

Higgins LJ, Yan F, Liu P, Liu H-W, Drennan CL. (2005) Structural Insight into Antibiotic Fosfomycin Biosynthesis by a Mononuclear Iron Enzyme. Nature437:838-844.  Full article

Berkovitch F, Behshad E, Tang KH, Enns EA, Frey PA, Drennan CL. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the X-ray structure of lysine-5,6-aminomutase. Proc. Natl. Acad. Sci. U.S.A. 101(45):15870-15875.  Full article

Midelfort KS, Hernandez HH, Lippow SM, Tidor B, Drennan CL, Wittrup KD. (2004) Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody. J. Mol. Biol. 343(3):685-701. Full article

Tirupati B, Vey JL, Drennan CL, Bollinger JM, Jr. (2004) Kinetic and Structural Characterization of Slr0077/SufS, the Essential Cysteine Desulfurase from Synechocystis sp. PCC 6803. Biochemistry 43:12210-12219.  Full article

Nicolet Y and Drennan CL. (2004) AdoMet Radical Proteins – from Structure to Evolution – Alignment of Divergent Protein Sequences Reveals Strong Secondary Structure Element Conservation. Nucleic Acids Res. 32:4015-4025. Full article

Drennan CL, Doukov TI, Ragsdale SW. (2004) The Metalloclusters of Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase: A Story in Pictures. J. Biol. Inorg. Chem. 9:511-515.  Full article

Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL. (2004) Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science303(5654):76-79.  Full article

Schreiter ER, Sintchak MD, Guo Y, Chivers PT, Sauer RT, Drennan CL. (2003) Crystal structure of the nickel-responsive transcription factor NikR. Nat. Struct. Biol. 10(10):794-799. Full article

Drennan CL and Peters JW. (2003) Surprising cofactors in metalloenzymes. Curr. Opin. Struct. Biol.13(2):220-226.  Full article

Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL. (2002) A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science298(5593):567-572. Full article

Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL. (2002) The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nat. Struct. Biol.9(4):293-300. Full article

Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW. (2001) Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc. Natl. Acad. Sci. U.S.A.98(21):11973-11978.  Full article

Marsh EN, Drennan CL. (2001) Adenosylcobalamin-dependent isomerases: New insights into structure and mechanism. Curr. Opin. Chem. Biol. 5(5):499-505.  Full article